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Refinement of adamantyl amines and -diamines targeting the Influenza A M2 ion channel. Numbers in parentheses are the relative potencies of the compounds measured as an x-fold increase or decrease in MIC50 compared to amantadine as positive control. 64 – 68: Influenza A (Ishikawa); 69 – 75: Influenza A2/Japan/305/1957 (H2N2). All compounds screened in MDCK cell culture assays.
