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. Author manuscript; available in PMC: 2014 May 8.
Published in final edited form as: Chem Rev. 2013 Feb 25;113(5):3516–3604. doi: 10.1021/cr100264t

Scheme 12.

Scheme 12

Fluoro-aminoadamantane 96 utilized in the 19F-NMR structure elucidation of M2TM peptide, aminoadamantanes 94 and 97–100 assayed in a Trp41 fluorescence-quenching assay. Values in parentheses are the binding constants to the model peptide and their potencies against Influenza A/Japan/305/57 (H2N2) as observed in an MDCK cell based assay, relative to amantadine