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. Author manuscript; available in PMC: 2014 May 8.
Published in final edited form as: Chem Rev. 2013 Feb 25;113(5):3516–3604. doi: 10.1021/cr100264t

Scheme 28.

Scheme 28

Aminoadamantanes and related compounds screened as tryptanocidals. Numbers in square brackets are ALOGPs data. Values in parentheses represent IC50 and IC90 data in μM. All values detected in vitro using T. brucei (strain 427) cultured in Iscove's medium at pH = 7.4 and 37 °C.