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. Author manuscript; available in PMC: 2014 May 8.
Published in final edited form as: Chem Rev. 2013 Feb 25;113(5):3516–3604. doi: 10.1021/cr100264t

Table 1.

Adamantanes as add-on to hypoglycemic sulfonylureas. graphic file with name nihms-449839-t0004.jpg

Substance R1 R2 ALOGPs relative potency (rat)
18 n-C4H9− -CH3 [2.04] 1
19 1-Adamantyl- -CH3 [2.78] 15.5
20 Cyclohexyl- -CH3 [2.65] 12.8
21 1-Adamantyl- -C2H5 [3.37] 14.8
22 3-Methyl-1-adamantyl- -CH3 [2.81] 2.8
23 3,5-Dimethyl-1-adamantyl- -CH3 [3.17] 0
24 Adamantyl-1-CH2− -C2H5 [4.09] 0.2