Table 2.
Odds ratios of breast cancer and 95% confidence intervals by weighted multi-SNP score and estrogen receptor status
| Weighted multi- SNP scorea |
Quintileb | All cases | ER+ cases | ER− cases | |||
|---|---|---|---|---|---|---|---|
| Cases/ controls |
OR (95% CI)c | Casesd | OR (95% CI) | Cases | OR (95% CI) | ||
| β-carotene | 1 (0.117) | 1530/1688 | 1.00 | 972 | 1.00 | 203 | 1.00 |
| 2 (0.174) | 1739/1887 | 1.02 (0.92,1.12) | 1116 | 1.02 (0.92,1.14) | 217 | 0.97 (0.79,1.18) | |
| 3 (0.291) | 2037/2115 | 1.06 (0.97,1.17) | 1333 | 1.08 (0.97,1.20) | 259 | 1.03 (0.84,1.25) | |
| 4 (0.408) | 1601/1614 | 1.10 (1.00,1.21) | 1038 | 1.11 (0.99,1.24) | 204 | 1.06 (0.86,1.31) | |
| 5 (0.466) | 1281/1356 | 1.04 (0.94,1.16) | 824 | 1.04 (0.93,1.17) | 152 | 0.95 (0.76,1.19) | |
| P-trende | 0.12 | 0.12 | 0.85 | ||||
| α-carotene | 1 (0.068) | 1698/1864 | 1.00 | 1075 | 1.00 | 221 | 1.00 |
| 2 (0.072) | 1787/1879 | 1.05 (0.95,1.15) | 1141 | 1.05 (0.95,1.17) | 226 | 1.00 (0.82,1.22) | |
| 3 (0.140) | 2037/2115 | 1.06 (0.96,1.16) | 1333 | 1.09 (0.98,1.20) | 259 | 1.02 (0.84,1.24) | |
| 4 (0.207) | 1491/1606 | 1.01 (0.92,1.12) | 967 | 1.04 (0.93,1.16) | 171 | 0.89 (0.72,1.10) | |
| 5 (0.212) | 1175/1196 | 1.08 (0.98,1.20) | 767 | 1.12 (0.99,1.26) | 158 | 1.11 (0.90,1.39) | |
| P-trend | 0.14 | 0.10 | 0.80 | ||||
| β-cryptoxanthin | 1 (0.031) | 1530/1688 | 1.00 | 972 | 1.00 | 203 | 1.00 |
| 2 (0.043) | 1739/1887 | 1.02 (0.92,1.12) | 1116 | 1.02 (0.92,1.14) | 217 | 0.97 (0.79,1.18) | |
| 3 (0.074) | 2037/2115 | 1.06 (0.97,1.17) | 1333 | 1.08 (0.97,1.20) | 259 | 1.03 (0.84,1.25) | |
| 4 (0.105) | 1601/1614 | 1.10 (1.00,1.21) | 1038 | 1.11 (0.99,1.24) | 204 | 1.06 (0.86,1.31) | |
| 5 (0.116) | 1281/1356 | 1.04 (0.94,1.16) | 824 | 1.04 (0.93,1.17) | 152 | 0.95 (0.76,1.19) | |
| P-trend | 0.12 | 0.11 | 0.84 | ||||
| Lutein/zeaxanthin | 1 (0.022) | 1707/1774 | 1.00 | 1095 | 1.00 | 198 | 1.00 |
| 2 (0.129) | 1529/1637 | 0.98 (0.89,1.08) | 973 | 0.98 (0.87,1.09) | 198 | 1.09 (0.89,1.35) | |
| 3 (0.152) | 2037/2115 | 1.00 (0.91,1.10) | 1333 | 1.03 (0.93,1.14) | 259 | 1.09 (0.90,1.33) | |
| 4 (0.174) | 1344/1423 | 0.98 (0.89,1.09) | 869 | 1.01 (0.90,1.13) | 181 | 1.14 (0.92,1.41) | |
| 5 (0.281) | 1571/1711 | 0.95 (0.87,1.05) | 1013 | 0.98 (0.87,1.09) | 199 | 1.02 (0.83,1.26) | |
| P-trend | 0.21 | 0.48 | 0.97 | ||||
| Retinol | 1 (0.008) | 1175/1196 | 1.00 | 767 | 1.00 | 158 | 1.00 |
| 2 (0.012) | 1491/1606 | 0.94 (0.84,1.04) | 967 | 0.93 (0.82,1.05) | 171 | 0.80 (0.63,1.00) | |
| 3 (0.020) | 2037/2115 | 0.97 (0.88,1.08) | 1333 | 0.97 (0.87,1.09) | 259 | 0.92 (0.74,1.14) | |
| 4 (0.028) | 1787/1879 | 0.96 (0.87,1.07) | 1141 | 0.94 (0.84,1.06) | 226 | 0.90 (0.72,1.12) | |
| 5 (0.032) | 1698/1864 | 0.92 (0.83,1.02) | 1075 | 0.89 (0.79,1.01) | 221 | 0.90 (0.72,1.12) | |
| P-trend | 0.18 | 0.10 | 0.78 | ||||
a
α-carotene = (0.06765*rs6564851 G)+(0.07195*rs12934922 T), β-carotene = (0.1744*rs6564851 G)+(0.1167*rs12934922 T), β-cryptoxanthin = (0.04268*rs6564851 G)+(0.03093*rs12934922 T), lutein/zeaxanthin = (0.1294*rs6564851 T)+(0.02225*rs12934922 T), and retinol = (0.008192*rs6564851 T)+(0.01206*rs12934922 A)
b
Values are median weighted multi-SNP scores by quintile
c
Adjusted for 5-year age category and study
d
Control numbers are equal across case subtypes
e
Trend for continuous weighted multi-SNP score adjusted for 5-year age category and study