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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2013 Mar 20;22(5):927–936. doi: 10.1158/1055-9965.EPI-13-0017

Table 3.

Odds ratiosa of ER+ breast cancer and 95% confidence intervals by weighted multi-SNP score quintile and alcohol intake

Weighted multi-SNP
scoreb 		Cases/
controls		 Quintile 1 Quintile 2 Quintile 3 Quintile 4 Quintile 5 P-
trendc 		P-
int.d
β-carotenee 0.117 0.174 0.291 0.408 0.466
  < 1 drink/day 4106/7146 1.00 1.02 (0.91,1.16) 1.08 (0.96,1.22) 1.08 (0.95,1.22) 1.01 (0.88,1.15) 0.52 0.05
  ≥ 1 drink/day 1018/1248 1.00 1.16 (0.89,1.51) 1.11 (0.86,1.44) 1.28 (0.97,1.68) 1.18 (0.89,1.57) 0.08
α-carotene 0.068 0.072 0.140 0.207 0.212
  < 1 drink/day 4106/7146 1.00 1.04 (0.92,1.17) 1.07 (0.95,1.20) 0.99 (0.87,1.12) 1.05 (0.92,1.20) 0.58 0.03
  ≥ 1 drink/day 1018/1248 1.00 1.08 (0.83,1.40) 1.10 (0.86,1.41) 1.20 (0.92,1.56) 1.37 (1.03,1.83) 0.04
β-cryptoxanthin 0.031 0.043 0.074 0.105 0.116
  < 1 drink/day 4106/7146 1.00 1.02 (0.91,1.16) 1.08 (0.96,1.22) 1.08 (0.95,1.22) 1.01 (0.88,1.15) 0.53 0.05
  ≥ 1 drink/day 1018/1248 1.00 1.16 (0.89,1.51) 1.11 (0.86,1.44) 1.28 (0.97,1.68) 1.18 (0.89,1.57) 0.07
Lutein/zeaxanthin 0.022 0.129 0.152 0.174 0.281
  < 1 drink/day 4106/7146 1.00 0.99 (0.88,1.13) 1.04 (0.93,1.17) 0.99 (0.87,1.13) 0.98 (0.86,1.10) 0.54 0.45
  ≥ 1 drink/day 1018/1248 1.00 0.98 (0.75,1.29) 0.98 (0.76,1.26) 1.04 (0.79,1.37) 1.02 (0.79,1.33) 0.86
Retinol 0.008 0.012 0.020 0.028 0.032
  < 1 drink/day 4106/7146 1.00 0.94 (0.82,1.08) 1.02 (0.90,1.16) 0.99 (0.87,1.13) 0.96 (0.84,1.09) 0.63 0.03
  ≥ 1 drink/day 1018/1248 1.00 0.87 (0.65,1.17) 0.80 (0.61,1.06) 0.78 (0.59,1.05) 0.73 (0.55,0.97) 0.03
a

Adjusted for 5-year age category, study, and continuous alcohol intake

b

α-carotene = (0.06765*rs6564851 G)+(0.07195*rs12934922 T), β-carotene = (0.1744*rs6564851 G)+(0.1167*rs12934922 T), β-cryptoxanthin = (0.04268*rs6564851 G)+(0.03093*rs12934922 T), lutein/zeaxanthin = (0.1294*rs6564851 T)+(0.02225*rs12934922 T), and retinol = (0.008192*rs6564851 T)+(0.01206*rs12934922 A)

c

Trend for continuous weighted multi-SNP score adjusted for 5-year age category, study, and continuous alcohol intake

d

P-value for interaction from likelihood ratio tests comparing models with and without the continuous weighted multi-SNP score by continuous alcohol intake (g/day) cross-product term adjusted for age category, study, and continuous alcohol intake

e

Values are median weighted multi-SNP scores by quintile