Table 2.
Base-Case Analysis: Cost and ATR Risk per AP Unit Transfused under Evaluated Strategies
| Cost to Prevent 1 ATR ($) | ||||||
|---|---|---|---|---|---|---|
| Cost of PAS ($) | Strategy 1 | Strategy 2 | Strategy 3 | Strategy 4 | Strategy 3f | Strategy 4g |
| 5 | ||||||
| Total Cost ($)a | 641.16 | 639.13 | 637.59 | 634.86 | --- | --- |
| Cost of Transfusion ($)b | 631.64 | 629.57 | 633.25 | 630.52 | ||
| Cost of ATRs ($)c | 9.52 | 9.56 | 4.34 | 4.34 | ||
| Change in Total Cost ($)d | 0.00 | −2.03 | −3.57 | −6.30 | ||
| 10 | ||||||
| Total Cost ($)a | 641.52 | 639.51 | 642.37 | 639.63 | 98.38 | --- |
| Cost of Transfusion ($)b | 631.76 | 629.74 | 638.14 | 635.40 | ||
| Cost of ATRs ($)c | 9.76 | 9.77 | 4.23 | 4.23 | ||
| Change in Total Cost ($) d | 0.00 | −2.01 | 0.85 | −1.89 | ||
| 15 | ||||||
| Total Cost ($) a | 641.44 | 639.44 | 647.49 | 644.76 | 701.95 | 384.86 |
| Cost of Transfusion ($)b | 631.75 | 629.72 | 643.21 | 640.47 | ||
| Cost of ATRs ($)c | 9.69 | 9.72 | 4.28 | 4.28 | ||
| Change in Total Cost ($)d | 0.00 | −2.00 | 6.05 | 3.32 | ||
| 25 | ||||||
| Total Cost ($)a | 641.10 | 639.21 | 657.13 | 654.39 | 1882.45 | 1561.17 |
| Cost of Transfusion ($)b | 631.67 | 629.77 | 653.00 | 650.26 | ||
| Cost of ATRs ($)c | 9.43 | 9.44 | 4.13 | 4.13 | ||
| Change in Total Cost ($)d | 0.00 | −1.89 | 16.03 | 13.30 | ||
| 50 | ||||||
| Total Cost ($)a | 641.52 | 639.88 | 682.23 | 679.49 | 4747.36 | 4428.24 |
| Cost of Transfusion ($)b | 631.83 | 630.17 | 677.91 | 675.17 | ||
| Cost of ATRs ($)c | 9.70 | 9.71 | 4.32 | 4.32 | ||
| Change in Total Cost ($)d | 0.00 | −1.65 | 40.70 | 37.97 | ||
| Average Across PAS Costs Evaluated | ||||||
| ATR Risk (%)e | 1.54 | 1.55 | 0.69 | 0.69 | ||
| Change in ATR Risk (%) | 0.20 | −55.42 | −55.42 | |||
Total cost per AP unit transfused includes direct medical expenses associated with the transfusion, any ATRs, and any AP manipulations.
Cost of Transfusion includes any direct medical expenses associated with the initial procedure, any AP manipulation, and any modified transfusion procedure.
Cost of ATRs includes any direct medical expenses associated with diagnosis, treatment, and monitoring of a mild or severe ATR.
Change in total cost calculated using Strategy 1 total cost as the baseline. Negative values represent cost savings.
ATR Risk calculated as an average across evaluated costs of PAS ($5, 10, 15, 25, 50)
Cost to avert 1 ATR calculated by comparing the costs and rate of ATRs between Strategy 1 and Strategy 3. Strategy 3 is cost-saving compared to Strategy 1 when PAS costs $5.
Cost to avert 1 ATR calculated by comparing the costs and rate of ATRs between Strategy 1 and Strategy 4. Strategy 4 is cost-saving compared to Strategy 1 when PAS costs $5 or $10.