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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Biochim Biophys Acta. 2012 Apr 4;1830(7):3946–3955. doi: 10.1016/j.bbagen.2012.03.015

Fig. 1.

Fig. 1

Physiological significance of D3. A, Ontogeny and relative level of D3 activity in rodent tissues (patterns are approximate, based on cited literature). Note that D3 activity is reduced by one or two orders of magnitude in most tissues from fetal life to adulthood. B, Ontogeny of serum thyroid hormone levels in normal animals and in D3KO mice. During development D3KO mice are exposed to excessive levels of T3. Values are expressed as a percentage of normal adult values (horizontal dotted line). C, Summary of reported phenotypes in D3KO mice.