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. 2012 Sep 26;18(3):244–250. doi: 10.1007/s12199-012-0307-5

Fig. 1.

Fig. 1

Nicotine metabolites. Around 80 % of nicotine is oxidized to cotinine, mainly by cytochrome P450 2A6 (CYP 286) [19, 20]. Nicotine and cotinine glucuronides were hydrolyzed to nicotine and cotinine and measured as total nicotine and cotinine (sum of free compound and glucuronides)