Figure 5.

Metabolic actions of NCoR1 and SMRT. Scheme of the functional consequences of NCoR1 and SMRT action in the entire mouse (A), in muscle (B), in liver (C), and in adipocytes (D). The phenotypes displayed by the mutant mice are listed, as these are logically inexistent in wild-type mice when NCoR1/SMRT achieves proper repression. Conversely, gain-of-function phenotypes of the SMRT^mRID1 mice are introduced by an arrow at the bottom of the panels. Details are found in the text. The transcription factors thought to mediate the effects are indicated. (TH) Thyroid hormone. Liganded TR is indicated by a square with a green circle.