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. 2013 Apr 15;27(8):916–927. doi: 10.1101/gad.214049.113

Figure 7.

Figure 7.

High NFIL3 expression and repression of FOXO targets are associated with poor prognosis in breast cancer. (A) qRT–PCR analysis with tumor samples shows NFIL3 is elevated in basal-like breast cancer. (B) Differential NFIL3 expression in luminal A and luminal B breast tumors (295 from van de Vijver set). (C) Kaplan-Meier analysis of same luminal samples; luminal B had a worse prognosis. (D–G) Kaplan-Meier analysis with 295 samples from the van de Vijver breast tumor data set. Samples were divided into two equal groups based on gene expression levels; these genes were repressed by NFIL3 and induced by FOXO1. (H) Kaplan Meier analysis with the 249 non-basal-like breast cancer samples from NKI (Netherlands Cancer Institute) data set; NFIL3 expression is associated with poor prognosis.