Table 1.

Pharmacokinetic parameters of duloxetine after a single dose including the 3 dose groups and multiple dosage in Chinese volunteers

Values are presented as mean±standard deviation.

T_1/2, elimination half-life; T_max, time to C_max; C_max, maximum observed concentration; K_e, the rate of elimination; V_1/F, initial volume of distribution; C_L/F, oral system clearance; MRT_0-t, the mean residence time of 0-120 min; AUC_0-t, area under concentration time curve (AUC) from time zero to definite time; AUC_0-∞, AUC from time zero to infinity; AUC_ss, AUC in steady-state.