Table I. Significantly modulated proteins in gastrocnemius muscle of 3-week-old dystrophin deficient mdx mice relative to C57BL/6 mice.
| Accessiona | Protein nameb | Fold changec |
|---|---|---|
| P20152 | Vimentin | 3.51 |
| P07356 | Annexin A2 | 3.18 |
| P31001 | Desmin | 2.69 |
| Q6ZWV3 | 60S ribosomal protein L10 | 2.46 |
| P35979 | 60S ribosomal protein L12 | 2.25 |
| P19253 | 60S ribosomal protein L13a | 2.18 |
| P62242 | 40S ribosomal protein S8 | 2.09 |
| P35980 | 60S ribosomal protein L18 | 2.03 |
| P62908 | 40S ribosomal protein S3 | 2.02 |
| Q6ZWN5 | 40S ribosomal protein S9 | 1.99 |
| Q9CXW4 | 60S ribosomal protein L11 | 1.99 |
| P67984 | 60S ribosomal protein L22 | 1.96 |
| P14131 | 40S ribosomal protein S16 | 1.95 |
| P68040 | Guanine nucleotide-binding protein subunit beta-2-like 1 | 1.94 |
| Q8BTM8 | Filamin-A | 1.88 |
| O88990 | Alpha-actinin-3 | 1.79 |
| Q9JI91 | Alpha-actinin-2 | 1.79 |
| P26039 | Talin-1 | 1.77 |
| P15864 | Histone H1.2 | 1.77 |
| Q00897 | Alpha-1-antitrypsin 1–4 | 1.74 |
| Q921I1 | Serotransferrin | 1.71 |
| P62962 | Profilin-1 | 1.65 |
| P07724 | Serum albumin | 1.64 |
| P97457 | Myosin regulatory light chain 2, skeletal muscle isoform | 1.64 |
| P01027 | Complement C3 | 1.61 |
| P14824 | Annexin A6 | 1.55 |
| P99024 | Tubulin beta-5 chain | 1.52 |
| P68372 | Tubulin beta-2C chain | 1.47 |
| P20029 | 78 kDa glucose-regulated protein | 1.46 |
| Q9ERD7 | Tubulin beta-3 chain | 1.43 |
| Q9JK37 | Myozenin-1 | 1.42 |
| Q8VHX6 | Filamin-C | 1.42 |
| P48036 | Annexin A5 | 1.39 |
| Q99PT1 | Rho GDP-dissociation inhibitor 1 | 1.38 |
| P23953 | Liver carboxylesterase N | 1.36 |
| Q62234 | Myomesin-1 | 1.29 |
| P63101 | 14–3-3 protein zeta/delta | 1.28 |
| Q9CQZ5 | NADH dehydrogenase (ubiquinone) 1α subcomplex subunit 6 | 1.25 |
| Q3V1D3 | AMP deaminase 1 | 1.25 |
| Q8QZY1 | Eukaryotic translation initiation factor 3 subunit L | 1.23 |
| Q9ERS2 | NADH dehydrogenase (ubiquinone) 1α subcomplex subunit 13 | 1.22 |
| Q9WUB3 | Glycogen phosphorylase, muscle form | 1.21 |
| P20108 | Thioredoxin-dependent peroxide reductase, mitochondrial | 1.18 |
| P99029 | Peroxiredoxin-5, mitochondrial | 1.17 |
| Q64727 | Vinculin | 1.17 |
| Q9D051 | Pyruvate dehydrogenase E1 component subunit β mitochondrial | 1.07 |
| Q9D6R2 | Isocitrate dehydrogenase (NAD) subunit α, mitochondrial | −1.12 |
| Q99KI0 | Aconitate hydratase, mitochondrial | −1.12 |
| P47934 | Carnitine O-acetyltransferase | −1.15 |
| P48962 | ADP/ATP translocase 1 | −1.17 |
| Q9WUZ7 | SH3 domain-binding glutamic acid-rich protein | −1.17 |
| O55126 | Protein NipSnap homolog 2 | −1.18 |
| P32848 | Parvalbumin alpha | −1.18 |
| P41216 | Long-chain-fatty-acid–CoA ligase 1 | −1.19 |
| Q61425 | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | −1.21 |
| Q6P8J7 | Creatine kinase, sarcomeric mitochondrial | −1.23 |
| Q99JY0 | Trifunctional enzyme subunit beta, mitochondrial | −1.23 |
| P51174 | Long-chain specific acyl-CoA dehydrogenase, mitochondrial | −1.24 |
| Q8BMS1 | Trifunctional enzyme subunit alpha, mitochondrial | −1.25 |
| P42125 | 3,2-trans-enoyl-CoA isomerase, mitochondrial | −1.27 |
| P05201 | Aspartate aminotransferase, cytoplasmic | −1.29 |
| P13412 | Troponin I, fast skeletal muscle | −1.35 |
| P16125 | l-lactate dehydrogenase B chain | −1.36 |
| P11404 | Fatty acid-binding protein, heart | −1.38 |
| A2ASS6 | Titin | −1.43 |
| P68033 | Actin, alpha cardiac muscle 1 | −1.64 |
| P68134 | Actin, alpha skeletal muscle | −1.65 |
| P13541 | Myosin-3 | −1.71 |
| P13542 | Myosin-8 | −1.83 |
| Q5SX40 | Myosin-1 | −1.86 |
| Q5SX39 | Myosin-4 | −2.12 |
| P58771 | Tropomyosin alpha-1 chain | −2.33 |
| P58774 | Tropomyosin beta chain | −2.63 |
a Accession numbers are from the Uniprot database.
b Protein names are from the Uniprot database; significantly different protein modulations (p < 0.05) were determined using the non-parametric Wilcoxson rank sum test.
c Fold changes were calculated using mdx/wt (unlabeled/labeled) ratios quantitated using Integrated Proteomics Pipeline software. Ratios were obtained from n = 3 mice/group.