Fig. 3.
Calcium signaling pathways identified in the sporozoite proteome. A composite model of known calcium-dependent signaling molecules and their related pathways mainly identified from asexual blood stages are illustrated in this model and depicted based on their presence in the sporozoite proteome. Sporozoite proteins are colored according to their presence in both P. falciparum and P. yoelii sporozoites (orange) or their absence from both species (gray). Two endoplasmic-reticulum-associated receptors (inositol trisphosphate receptor (IP3R) and ryanodine receptor (RyR), in green) have no identified orthologous genes but have been detected based on the chemical inhibition of their functions. The triggering stimuli for rhoptry release and the directionality of the Non-SERCA calcium pump are not known and are denoted by question marks.