Table II. Cox multivariate regression analysis of prognostic factors of CRKL, FLT1, or CRKL/FLT1 expression for disease-free survival (DFS) and overall survival (OS) in 192 HCC patients.

Factors	CRKL		FLT1		CRKL/FLT1
	HRb (95% CIc)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Disease-free survival
CRKL (low vs. high)	1.579 (1.125–2.216)	0.008a
FLT1 (low vs. high)			1.275 (0.912–1.783)	0.156
CRKL/FLT1 (others vs. high/high)					1.271 (1.043–1.549)	0.018a
Stage (I and II vs. III)	1.687 (1.153–2.469)	0.007a	1.706 (1.161–2.507)	0.007a	1.679 (1.146–2.458)	0.008a
AFPd (<400 vs. ≥400 ng/ml)	1.147 (0.737–1.786)	0.543	1.076 (0.687–1.686)	0.750	1.090 (0.699–1.699)	0.703
Major vessel invasion (yes vs. no)	1.904 (1.117–3.246)	0.018a	2.040 (1.204–3.457)	0.008a	1.954 (1.148–3.325)	0.014a
Overall survival
CRKL (low vs. high)	1.747 (1.186–2.573)	0.005a
LT1 (low vs. high)			1.289 (0.886–1.876)	0.185
CRKL/FLT1 (others vs. high/high)					1.313 (1.052–1.638)	0.016a
Stage (I and II vs. III)	1.694 (1.139–2.517)	0.009a	1.686 (1.130–2.514)	0.01a	1.687 (1.134–2.509)	0.010a
AFP (<400 vs. ≥400 ng/ml)	1.326 (0.857–2.051)	0.205	1.297 (0.833–2.019)	0.249	1.280 (0.825–1.984)	0.271
Major vessel invasion (yes vs. no)	1.694 (1.054–2.571)	0.031a	1.881 (1.111–3.185)	0.019a	1.799 (1.060–3.053)	0.029a

^a p < 0.05.

^b HR represents hazard ratio.

^c CI represents confidence interval.

^d AFP represents α-fetoprotein.