TABLE 1.

Rat model of myocardial infarction shows compensated hypertrophy at 4 weeks with decompensation by 16 weeks

Heart weight/body weight ratios reveal a hypertrophic response at both time points compared with controls, although it is significantly greater at 4 weeks. Echocardiography reveals a reduced ejection fraction at both time points compared with controls, but it is further reduced by 16 weeks compared with 4 weeks post-MI. Numeric values for ejection fraction and heart weight/body weight ratios are stated as mean ± S.E. with n numbers accompanying each value. HW/BW, heart weight/body weight; AMC, age-matched control.

	Ejection fraction		HW/BW
	AMC	MIa	AMC	MI
4 weeks	78.6 ± 3.89 (n = 9)	43.3 ± 3.89 (n = 9)	3.43 ± 0.17 (n = 9)	4.84 ± 0.17b (n = 9)
16 weeksc	74.5 ± 4.12 (n = 8)	30.9 ± 3.89 (n = 9)	2.85 ± 0.18d (n = 8)	3.43 ± 0.17e (n = 9)

^a Significant main MI treatment effect (p < 0.001).

^b Significant MI effects, within 4-week pairing (p < 0.001).

^c Significant main recovery time effect (p = 0.046).

^d Significant recovery time effect within AMC pairing (p = 0.023).

^e Significant MI effect within 16-week pairing (p = 0.024) and significant recovery time effect within MI pairing (p < 0.001).