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. 2013 Apr 3;288(19):13534–13550. doi: 10.1074/jbc.M113.457218

FIGURE 5.

FIGURE 5.

Overexpression of DAI promotes ALD-DNA-induced macrophage activation. RAW-Vector and RAW-DAI cells were stimulated with ALD-DNA, UnALD-DNA, or PBS. A, 24 h after stimulation, levels of TNF-α, IL-6, IL-12, IL-1β, IL-10, MCP-1, IFN-β, and nitrite (the inducible NO synthase, iNOS) in the culture supernatants were measured by ELISA. B, RAW-Vector and RAW-DAI cells were stimulated with increasing amounts of ALD-DNA for 24 h, and cytokine expression levels of TNF-α, IL-6, IL-10, and IFN-β in the culture supernatants were measured by ELISA. Data are mean ± S.E. of three independent experiments. *, p < 0.05; **, p < 0.01; ***, p < 0.001; NS, not significant.