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Structural variety of TNFα in free form and TNFα-TNFR2 and TNFα-infliximab Fab complexes. The free state of the molecule is colored gray. TNFα molecules in the TNFα-TNFR2 and TNFα-infliximab Fab complex structures are colored red and cyan, respectively. The variant parts of the C-D and E-F loops of TNFα are framed.
