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Model for MSK2 regulation of p53 activity at the Noxa promoter. In the absence of stimuli, MSK2 suppresses Noxa transcription by interfering with p300 cotranscriptional activity and p300-mediated p53 acetylation. Apoptotic stimuli, such as UVC and cisplatin, trigger MSK2 degradation alleviating the repression of p300 and allowing p53-mediated transcriptional activation of the Noxa promoter.
