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. 2013 May 10;3:102. doi: 10.3389/fonc.2013.00102

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Copyright © 2013 Jain and Jackson.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.

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(A,C,E) Typical trajectories of a cell migrating across a 2-dimensional domain under the influence of VEGF. Here, A represents the concentration of activated VEGFR2 per cell face and A_max represents the maximum value A can take so that A/A_max is the fraction of activated VEGFR2 per cell face expressed here as a percentage, and <A_grad> represents the gradient of A across a cell length, averaged over the entire domain. (B,D,F) Corresponding movement probabilities for various values of maximum VEGF concentration.