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. Author manuscript; available in PMC: 2013 May 10.
Published in final edited form as: Am J Physiol Lung Cell Mol Physiol. 2008 Jan 18;294(3):L523–L534. doi: 10.1152/ajplung.00328.2007

Fig. 3.

Fig. 3

NKR subtype-selective agonist effects on intracellular Ca2+ concentration ([Ca2+]i). A: representative trace of time plotted against fluorescence intensity (ΔF/Fo) illustrating the characteristics of the NKR agonist-induced [Ca2+]i increase in HASM-NKxR cells. The responses to NKR agonists were “biphasic,” with a transient rise in [Ca2+]i followed by a sustained [Ca2+]i increase lasting many minutes. Int., interruption of fluorescence measurement due to drug addition. Dotted line indicates the estimated fluorescence intensity during the interruption. B: effects of selective NKR agonists [NK1R, 1 μM SM-SP; NK2R, 1 μM β-ala-NKA; NK3R, 1 μM senktide] and vehicle control (modified HBSS) on [Ca2+]i in native cultured HASM cells. Peak fluorescence increase was measured and expressed as a maximum compared with basal values (F/Fo). Data are means ± SE. *P < 0.05; **P < 0.01 compared with vehicle control. Numbers in parentheses indicate the number of experiments.