Fig 5.
Comparative residue frequencies in the IBP and RBP ligand-binding cavities. Residue numbering is based on the IbpA sequence. For the amino acid sequence alignment used to produce this figure, see Fig. S1 in the supplemental material. (A) Residue frequency in the ligand-binding cavities of IBPs. The residue at each of these positions in Caulobacter IbpA is in red. (B) Residue frequency in the ligand-binding cavities of RBPs. The residue at each of these positions in Caulobacter IbpA is in red. The residues at positions 169 and 174 are not involved in ligand interaction and are in gray. (C) Spatial organization of the N168-S203 pair in IbpA and the G169-F203 pair in RBPTt (PDB code 2IOY). myo-Inositol and ribose carbons are numbered.