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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Expert Opin Ther Targets. 2012 Sep 24;16(12):1161–1174. doi: 10.1517/14728222.2012.726985

Figure 2. p53 inactivation enriches for stem cells.

Figure 2

Inactivation of p53 by deletion, mutation, or dominant-negative isoforms of p53 family members enriches stem cell populations that include cancer stem cells (CSCs), induced pluripotent stem cells (iPSCs) and hematopoietic stem cells (HSCs). p53 is known to regulate self-renewal and differentiation of embryonic stem cells (ESCs). Some of these genes such as P-gp and miR-34 are direct targets of p53 activity whereas others such as Notch and c-myc are transcription factors that crosstalk with the p53 pathway and drive stem-like characteristics. Described mechanisms of p53 inactivation are noted for each stem cell type along with genes that are important for the specific population and that intersect with the p53 pathway.