Table 1.
6 hours
|
24 hours
|
48 hours
|
72 hours
|
|||||
---|---|---|---|---|---|---|---|---|
Low SM | High SM | Low SM | High SM | Low SM | High SM | Low SM | High SM | |
Erythema–Draize† | 3.42 ± 0.72‡ | 3.83 ± 0.38‡ | 3.78 ± 0.43‡ | 4.00 ± 0.00*,‡ | 2.83 ± 1.03‡ | 4.00 ± 0.00*,‡,§ | 3.50 ± 0.55‡ | 4.00 ± 0.00‡ |
Erythema Δa* | 8.69 ± 1.45‡ | 8.73 ± 1.94‡ | 5.44 ± 2.43‡ | 5.67 ± 1.56‡ | 5.31 ± 2.79‡ | 7.24 ± 1.65‡ | 3.83 ± 1.12‡ | 8.59 ± 2.67*,‡,§ |
Edema–Draize¶ | 0.00 ± 0.00 | 0.00 ± 0.00 | 2.39 ± 0.78 | 4.00 ± 0.00*,‡,§ | 1.75 ± 1.42‡ | 4.00 ± 0.00*,‡,§ | 2.33 ± 1.37‡ | 4.00 ± 0.00*,‡,§ |
Results are the mean ± SD of values from 18 skin sites, except for day 1 where n = 24.
Scores: 1, very slight erythema; 2, well-defined erythema; 3, moderate to severe erythema; 4, severe erythema.
Significantly different from mean air control value.
Significantly different from mean low dose value.
Scores: 1, very slight edema; 2, slight edema; 3, moderate edema; 4, severe edema.