Figure 1.

Tumor tissue structure as a barrier in drug and imaging agent efficacy. (A) Schematics of the complex dynamics of drug/imaging molecule movement through the tissue, including extravasation, diffusive and advective transport, and internalization. (B) Three-dimensional multiphoton emission (MPE) microscopy image reconstruction (400× magnification) of the human MDAMB231/GFP xenograft tumor from the dorsal-skin fold window chamber. (C) Horizontal view of (B) showing the depth in the tissue structure. Staining: green-tumor cells, red-vasculature.