Table IV.
Additional Anomalies, Ages at Detection, and Final Diagnoses in 38 Infants with Isolated Clefts Reassigned to the Associated Group.
| Reason for reassignment |
Age at diagnosis | ||||
|---|---|---|---|---|---|
| 7 days (N=22) | 28 days (N=10) | 6 months(N=2) | 12 months (N=3) | NS(N=1) | |
| Major anomalies (syndromes) (N=5) |
Chrom (CHD)(1) | OPD (CHD)(3) Fraser (NS)(1) Moebius (hydrocephaly)(3) Rubella (cataract)(3) |
|||
| Major anomalies (MCAs) (N=19) |
Cystic kidney R(1) Ectopic anus(1) Hydronephrosis R(1) Dandy Walker(1) CHD+Microcephaly(1) CHD (2 cases)(1,1) |
CHD+kidney agenesis R(1) CHD (2 cases)(1,1) Brain anomaly(1) Thyroid agenesis(1) Cystic kidney R(1) |
CHD(1) Cystic kidney R(1) |
CHD(1) Anal stenosis (2 cases)(1,1) |
Cataract(1) |
| Minor anomalies (syndromes) (N=8) |
Chrom (3 cases)(2,3,**) Edward (2 cases)(1,1) Klinefelter(3) Rubinstein Taybi(3) Cornelia de Lange(3) |
||||
| Wrong assignment at birth (N=6) |
Chrom (3 cases)(1,2,3) Hydrops fetalis(3) Lethal skeletal dysplasia(3) MCA(3) |
||||
Additionally detected major anomalies in syndromes between parentheses
MCA: multiple congenital anomalies of unknown cause
Chrom: other chromosomal abnormalities
CHD: congenital heart defect; OPD: otopalatodigital type I syndrome
NS: not specified; R: right
1
CLP
2
CLO
3
CP