(A) Analysis of chemokine receptors in freshly isolated nTregs and ex vivo cultured eTregs and rTregs. Shown are flow cytometry dot plots for nTregs, eTregs and rTregs, stained with anti-CXCR4, CCR4, CCR5, CXCR3, CCR1, CCR3, CCR9 and CCR7 fluorochrome-conjugated mAb from 1 representative donor. The percentages shown represent the double positive cells (chemokine receptor and CD25+). (B) Comparative phenotypic analysis of chemokine receptors expression in freshly isolated nTregs and ex vivo cultured eTregs and rTregs. Bars (white for nTregs; black for eTregs and gray for rTregs) represent mean ± SD of 5 different donors.