Table 2.
Inhibitor | Viral Strain | |
---|---|---|
Phil82 H3N2 | PR-8 H1N1 | |
BALF | 2.6±0.86 | 12±3.7 |
BALF+Oseltamivir | 0.66±0.21* | 2.16±0.41* |
H-Ficolin | 1.8±0.16 | 0.36±0.07 |
Pentraxin 3 | >10 | >10 |
H-Ficolin+Pentraxin | 1.09±0* | 0.186±0.04** |
Results are expressed as mean±SEM of 4 experiments in μg/ml of H-ficolin or BALF protein resulting in inhibition of 40 Hemagglutinin units of the indicated strains of IAV. The concentration of oseltamivir added was 10μg/ml. Pentraxin 3 had no independent HA inhibitory activity in this assay up to the maximum concentration tested (i.e., 10 μg/ml). Note that BALF results are expressed as total BALF protein.
indicates where oseltamivir significantly reduced the amount of BALF protein needed to inhibit IAV.
indicates where the effect of the combination of H-ficolin and pentraxin was significantly greater than the effect of either protein alone.