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. Author manuscript; available in PMC: 2013 May 10.
Published in final edited form as: Sci Transl Med. 2012 May 9;4(133):133ra57. doi: 10.1126/scitranslmed.3003425

Figure 5. Evidence for stable disease in two patients at one year post-diagnosis.

Figure 5

Upper Series: MRI of the brain (P1). Axial T1 post gadolinium sequences at the level of midbrain. (A) Area of enhancement seen in left temporal lobe at initial presentation (arrow). Gross total resection was performed and histology confirmed glioblastoma, World Health Organization (WHO) Grade IV. (B) Area of enhancement and surrounding edema in left temporal lobe 6 months following diagnosis (interpreted as pseudoprogression). (C) Stable disease with faint area of linear enhancement at posterior margin of the resection cavity (arrow) 12 months following initial diagnosis (6 months following 2nd craniotomy) after 4 additional cycles of O6BG/TMZ chemotherapy. Lower series: MRI of the brain (P3). Axial T1 post gadolinium images. (D) Enhancing lesion in right parietal lobe (arrow) at initial presentation. (E) First post-radiation scan, enlargement of the enhancing area and associated vasogenic edema (arrow heads) are present (interpreted as possible pseudoprogression). (F) Six months from original diagnosis, after 2 cycles of O6BG/TMZ chemotherapy, area of enhancement has enlarged but surrounding edema has diminished and patient was clinically stable. (G) Eleven months from original diagnosis, after 2 additional doses of O6BG/TMZ chemotherapy. Stable area of contrast enhancement.