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. 2013 Feb 1;42(1):9. doi: 10.1186/1916-0216-42-9

Table 2.

Correlation of HPV status with patient and tumor factors

 
  
  
 All high-risk HPV
 HPV-16 only
Patient characteristic Total Negative Positive p* Negative Positive p*
Age
 <60
 51
 16
 35
 <0.001
 18
 33
 <0.001
> = 60
 44
 29
 15
  
 32
 12
  
Gender
 Male
 75
 32
 43
 0.08
 37
 38
 0.32
Female
 20
 13
 7
  
 13
 7
  
Subsite
 Tonsil
  
 21
 31
 0.02
 23
 29
 0.01
Base of Tongue
  
 10
 15
  
 12
 13
  
Other
  
 14
 4
  
 15
 3
  
T Classification
 1
 14
 4
 10
 0.27
 4
 10
 0.19
2
 25
 11
 14
  
 14
 11
  
3
 30
 18
 12
  
 19
 11
  
4
 26
 12
 14
  
 13
 13
  
N Classification
 0
 18
 13
 5
 0.09
 16
 2
 0.002
1
 13
 7
 6
  
 8
 5
  
2
 54
 21
 33
  
 22
 32
  
3
 10
 4
 6
  
 4
 6
  
Overal Stage
 1
 2
 1
 1
 0.49
 1
 1
 0.02
2
 9
 5
 4
  
 8
 1
  
3
 13
 8
 5
  
 10
 4
  
4
 71
 31
 40
  
 31
 39
  
Smoking
 never smokers
 20
 4
 16
 0.006
 5
 1
 0.001
1-9 py
 6
 2
 4
  
 2
 4
  
10-19 py
 6
 1
 5
  
 1
 5
  
>20 py
 57
 35
 22
  
 39
 18
  
Unknown
 6
 3
 3
  
 3
 3
  
Alcohol
 < 21 drinks
 70
 30
 40
 0.37
 34
 36
 0.45
(drinks/wk)
 >21 drinks
 17
 10
 7
  
 11
 6
  
Unknown
 8
 5
 3
  
 5
 3
  
Treatment
 CRT
 62
 29
 33
 0.78
 30
 32
 0.55
Radiation
 11
 5
 6
  
 8
 3
  
Induction + CRT
 13
 5
 8
  
 6
 7
  
Surgery + CRT
 5
 3
 2
  
 3
 2
  
Surgery + RT
 2
 1
 1
  
 1
 1
  
Surgery
 2
 2
 0
  
 2
 0
  
HPV Type
 16
 45
 0
 45
  
 0
 45
  
18
 2
 0
 2
  
 2
 0
  
33
 1
 0
 1
  
 1
 0
  
67
 2
 0
 2
  
 2
 0
  
p16 Negative
 35
 34
 1
 <0.001
 34
 1
 <0.001
Positive 59 10 49   15 44  

HPV human papillomavirus, py pack years, RT radiation, CRT chemoradiation.

* Fisher exact test.