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. Author manuscript; available in PMC: 2013 Oct 1.
Published in final edited form as: Nat Methods. 2013 Mar 17;10(4):361–365. doi: 10.1038/nmeth.2408

Figure 2.

Figure 2

Example of HeLa breakomes associated with specific treatments. (a) Genome-wide aphidicolin (orange) and neocarzinostatin (gray) sensitivity landscapes in HeLa cells, corrected for karyotype and aphidicolin effects. Bars represent the density per one Mb bin of 48 mappable kb ASRs corrected for copy number variation effects. Individual regions and mappability maps are shown in detail in Supplementary Fig. 4b, since non-mappability can artificially lower the number of significant regions per Mb. (b) Frequency distribution of genomic distances between the centers of consecutive aphidicolin- and neocarzinostatin-sensitive regions.