Table 2.
Haplotype/Multi-Gene Analysis With Inclusion of the Arg130Gln IL-13 SNP and the Associated Haplotype Phenotype
| Gene | SNPs | rs Signatures | Haplotype Associated Phenotype | Race Background | P Value if Available | Reference |
|---|---|---|---|---|---|---|
| IL13 | - 1512A/C | rs1881457 | Severe RSV infection asthma | German children < 2 years old, | 0.009 (FASTEHPLUS) | ([100]) |
| - 1112C/T | rs1800925 | hospitalized for RSV | 0.01183 (FAMHAP) | |||
| Arg130Gln | rs20541 | |||||
| IL4 + IL13 | - 589C/T | rs2243250 | Severe RSV infection asthma | German children < 2 years old, | 0.0008 (FASTEHPLUS) | ([100]) |
| - 1512A/C | rs1881457 | hospitalized for RSV | 0.0011 (FAMHAP) | |||
| - 1112C/T | rs1800925 | |||||
| Arg130Gln | rs20541 | |||||
| IL4Rα + IL13 | Ile50Val Arg130Gln | Asthma + IgE levels | Chinese children 5 to 18 years of age | 0.013 (GMDR) | ([104]) | |
| IL4 + IL13 | - 589C/T | Atopic dermatitis | Canadian children with family | 0.006 | ([95]) | |
| Arg130Gln | Atopy (Asthma not investigated) | history of asthma or atopy | 0.009 |
GMDR = Generalized multifactor dimensionality reduction method.