Table 2. Biodistribution of 99mTc(CO)3-Z08698-H6 and 99mTc(CO)3-Z08699-H6 in female NMRI mice 4 h after injection.
99mTc(CO)3-Z08698-H6 | 99mTc(CO)3-Z08699-H6 | |||
1 µg | 10 µg | 1 µg | 10 µg | |
blood | 0.8±0.1a, c | 0.60±0.05 | 1.1±0.1b | 0.6±0.1 |
lung | 2.3±0.4c | 2.3±0.7 | 3.4±0.3b | 2.6±0.3 |
liver | 12±2a | 7.8±0.7 | 11±2b | 6.6±1.0 |
spleen | 1.4±0.3 | 1.7±0.3 | 1.4±0.2 | 1.2±0.2 |
stomach | 4.0±0.5a | 2.2±0.2 | 4.6±0.2b | 2.6±0.4 |
sm intest | 8.6±0.6a, c | 2.4±0.1 | 7.7±0.5b | 2.7±0.5 |
kidney | 85±17a, c | 146±16 | 131±8b | 163±25 |
uterus | 0.9±0.1a, c | 1.2±0.1d | 1.5±0.1 | 1.6±0.3 |
saliv gland | 2.3±0.2a | 1.1±0.3 | 2.9±0.5b | 1.4±0.1 |
muscle | 0.33±0.05c | 0.33±0.09 | 0.44±0.06 | 0.38±0.04 |
bone | 0.8±0.2 | 0.9±0.1 | 0.9±0.1 | 0.87±0.06 |
carcass* | 10.5±0.7c | 10.7±1.0 | 12.7±1.6 | 11.1±0.9 |
Data are expressed as per cent of injected activity per gram and presented as an average (n = 4) and standard deviation.
Data for carcass are presented as per cent of injected activity per whole sample.
significant difference (p<0.05) between uptake after injection of 1 and 10 µg of 99mTc(CO)3-Z08698-H6;
significant difference (p<0.05) between uptake after injection of 1 and 10 µg of 99mTc(CO)3-Z08699-H6;
significant difference (p<0.05) between uptake after injection of 1 µg of 99mTc(CO)3-Z08698-H6 and 99mTc(CO)3-Z08699-H6;
significant difference (p<0.05) between uptake after injection of 10 µg of 99mTc(CO)3-Z08698-H6 and 99mTc(CO)3-Z08699-H6;