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. 2013 May 10;8(5):e62791. doi: 10.1371/journal.pone.0062791

Table 2. Biodistribution of 99mTc(CO)3-Z08698-H6 and 99mTc(CO)3-Z08699-H6 in female NMRI mice 4 h after injection.

99mTc(CO)3-Z08698-H6 99mTc(CO)3-Z08699-H6
1 µg 10 µg 1 µg 10 µg
blood 0.8±0.1a, c 0.60±0.05 1.1±0.1b 0.6±0.1
lung 2.3±0.4c 2.3±0.7 3.4±0.3b 2.6±0.3
liver 12±2a 7.8±0.7 11±2b 6.6±1.0
spleen 1.4±0.3 1.7±0.3 1.4±0.2 1.2±0.2
stomach 4.0±0.5a 2.2±0.2 4.6±0.2b 2.6±0.4
sm intest 8.6±0.6a, c 2.4±0.1 7.7±0.5b 2.7±0.5
kidney 85±17a, c 146±16 131±8b 163±25
uterus 0.9±0.1a, c 1.2±0.1d 1.5±0.1 1.6±0.3
saliv gland 2.3±0.2a 1.1±0.3 2.9±0.5b 1.4±0.1
muscle 0.33±0.05c 0.33±0.09 0.44±0.06 0.38±0.04
bone 0.8±0.2 0.9±0.1 0.9±0.1 0.87±0.06
carcass* 10.5±0.7c 10.7±1.0 12.7±1.6 11.1±0.9

Data are expressed as per cent of injected activity per gram and presented as an average (n = 4) and standard deviation.

*

Data for carcass are presented as per cent of injected activity per whole sample.

a

significant difference (p<0.05) between uptake after injection of 1 and 10 µg of 99mTc(CO)3-Z08698-H6;

b

significant difference (p<0.05) between uptake after injection of 1 and 10 µg of 99mTc(CO)3-Z08699-H6;

c

significant difference (p<0.05) between uptake after injection of 1 µg of 99mTc(CO)3-Z08698-H6 and 99mTc(CO)3-Z08699-H6;

d

significant difference (p<0.05) between uptake after injection of 10 µg of 99mTc(CO)3-Z08698-H6 and 99mTc(CO)3-Z08699-H6;