Table 3. Biodistribution of ^99mTc(CO)₃-Z₀₈₆₉₉-H₆ in male BALB/C nu/nu mice bearing LNCaP prostate cancer xenografts at 6 h after injection.

	Uptake		Tumor-to-organ ratio
	0.1 µg	1 µg	0.1 µg	1 µg
blood	0.77±0.04a	0.63±0.03	2.4±0.7a	4.7±1.3
salivary gland	9.3±2.3a	5.2±0.4	0.20±0.01a	0.56±0.15
lung	1.82±0.09	2.1±0.3	1.0±0.3	1.4±0.2
liver	16.8±1.1a	11.9±0.9	0.11±0.03a	0.25±0.06
spleen	1.5±0.2	1.4±0.6	1.2±0.3	2.2±0.8
stomach	5.4±0.9	4.1±0.2	0.4±0.1	0.7±0.2
small intestines	10±3	12±3	0.17±0.03	0.24±0.04
kidney	77±9a	130±24	0.02±0.01	0.02±0.01
tumor	1.9±0.8	2.9±0.8
muscle	0.23±0.02	0.26±0.05	8.0±2.0	11±2
bone	0.6±0.1	0.6±0.2	2.8±0.9a	5.5±1.4
carcass*	10.9±0.3a	13±1

Data are expressed as per cent of injected activity per gram and presented as an average (n = 4) and standard deviation.

^*Data for carcass are presented as per cent of injected activity per whole sample.

^aSignificant difference between biodistribution after injection of 0.1 and 1 µg of ^99mTc(CO)₃-Z₀₈₆₉₉-H₆ per mouse.