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. 2013 May 10;8(5):e63440. doi: 10.1371/journal.pone.0063440

Figure 7. Kaplan–Meier analysis of survival (up to 5 years) of HNSCC patients.

Figure 7

a) Co-alteration of CDC25A and SH3GL2 was significantly associated with poor overall survival (OS). b) The significant association with poor overall survival of patients having co-alterations of the genes was also seen in presence of HPV infection; however, co-alterations did not associate significantly with OS in absence of HPV infection (c). d) Poor survival was also seen of the patients having high EGFR expression irrespective of HPV infection. d) Similarly, reduced SH3GL2 expression and high EGFR expression was a predictor for poor OS. However f), protein expression of p-EGFR and CDC25A did not show any significant association with survival of the patients. Survival time was defined as the time from the date of surgery to the date of last follow-up, known recurrence or death (up to 5 years). n, total number of samples; C+/−, CDC25A deletion present/absent; S+/−, SH3GL2 alterations present/absent; H+/−, HPV infection present/absent; EH/ML, EGFR protein expression high/medium to low; S-L/MH, SH3GL2 protein expression low/medium to high; C-H/ML, CDC25A protein expression high/medium to low; p-EH/LM, p-EGFR protein expression high/low to medium.