. 2013 May 10;8(5):e63440. doi: 10.1371/journal.pone.0063440

Table 2. Correlation of molecular alterations with RNA/protein expression of the genes SH3GL2 and CDC25A and the relationship between the protein expression of EGFR vs SH3GL2 and CDC25A vs p-EGFR.

	EGFR					SH3GL2				CDC25A					p-EGFR¹⁰⁴⁵
	Genetic	Expression				Genetic	Expression			Genetic		Expression			Expression
	Altn	RNA		Protein		Altn	RNA		Protein	Altn		RNA		Protein	Protein
Dysplastic lesions
L7	Amp−	ND		++		D−M−	ND		+++	D−		ND		++	++
L48	Amp−	ND		+++		D−M+	ND		++	D−		ND		+++	+
L50	Amp+	ND		+++		D−M+	ND		++	D−		ND		++	++
L52	Amp−	ND		++		D+M−	ND		+	D−		ND		+++	++
L58	Amp−	ND		+++		D−M+	ND		+	D−		ND		+++	+
L127	Amp−	ND		+++		D+M+	ND		+	D+		ND		+	+++
HNSCC cell line
Hep2	Amp−	Normal		+++		D−M+	↓		+	D−		↓		++	++
SCC084	Amp−	Normal		+		D−M−	Normal		+++	D−		Normal		+++	++
KB	Amp−	Normal		++		D−M−	Normal		+++	D−		Normal		+++	++
HNSCC samples
3689	Amp−	Normal		++		D−M+	↓		++	D−		Normal		++	++
7077	Amp−	Normal		+++		D−M+	↓↓		++	D+		↓↓		+	+++
2649	Amp−	Normal		+++		D+M−	↓		+	D+		↓↓		+	+++
4465	Amp−	Normal		+++		D−M+	↓		++	D−		Normal		+++	+
3371	Amp+	↑		+++		D−M+	↓		++	D−		↓		+++	+
315	Amp−	Normal		+++		D+M−	↓↓		+	D−		Normal		++	++
3187	Amp−	Normal		+++		D+M+	↓↓		+	D−		Normal		+++	+
5999	Amp−	Normal		+++		D+M−	↓		+	D+		↓↓		+	+++
5314	Amp−	Normal		++		D−M+	↓↓		++	D+		↓↓		+	+++
91	Amp−	Normal		+++		D−M+	↓		++	D−		Normal		++	++
403	Amp−	Normal		+++		D+M+	↓↓		++	D−		Normal		+++	+
3910	Amp−	Normal		+++		D−M+	↓		++	D−		↓		++	++
2496	Amp−	Normal		+++		D+M+	↓↓		+	D+		↓↓		+	+++
4892	Amp+	↑		+++		D+M−	↓↓		+	D−		↓		++	++
2935	Amp−	Normal		+++		D−M+	↓		++	D−		↓		++	++
5232	Amp−	Normal		+++		D+M+	↓↓		+	D+		↓		+	+++
3484	Amp−	Normal		+++		D+M+	↓↓		+	D−		Normal		+++	+
3489	Amp−	Normal		+++		D−M+	↓		++	D−		↓		++	++
51	Amp+	↑		+++		D+M+	↓↓		+	D−		Normal		++	++
4283	Amp−	Normal		+++		D+M−	↓↓		+	D+		↓↓		+	+++
2333	Amp−	Normal		++		D−M−	Normal		+++	D+				+	+++
1416	Amp−	Normal		+++		D+M−	↓↓		+	D+		↓↓		+	+++
p value	0.0025*		0.5528		0.00043*			0.00003*			0.0027*		0.011*		0.00005*
				0.0011*									0.0117*

D+/−: Deletion (MA, LOH) positive/negative, M+/−: Methylation positive/negative,/: increased/decreased gene expression compared to normal. ND: Fresh tissues were unavailable for RNA isolation, *: statistically significant (p<0.05).