Table 1.

Conditions associated with Hypereosinophilia (HE)

Reactive conditions

Helminth infections

Allergic reactions

Atopic diseases

Drug reactions (allergic or toxic)

Scabies, other infestations

Allergic bronchopulmonary aspergillosis

Autoimmune diseases

Other chronic inflammatory diseases

Chronic graft-vs-host disease

Lymphocytic/lymphoid variant HES

Neoplastic conditions involving the hematopoietic system (see Table 2)

Myeloid neoplasms

Mast cell neoplasms

Lymphoid neoplasms

Paraneoplastic conditions

Solid tumors/malignancy

Lymphoproliferative neoplasms

Idiopathic forms

Idiopathic eosinophilia

HE of uncertain (undetermined) significance

Idiopathic HES

Rare syndromes associated with HE

Gleich syndrome

CSS

EMS

Omenn syndrome

Hyper IgE syndrome

Hereditary HE (not otherwise specified)

CSS, Churg-Strauss Syndrome; EMS, Eosinophilia Myalgia Syndrome.