Table 2.

Hematopoietic Neoplasms Accompanied by Eosinophilia

Neoplasms in which eosinophils are likely to be clonal cells

Acute eosinophilic leukemia

CEL

Acute myeloid leukemia with inv(16) (FAB AML M4eo)

Chronic myeloid leukemia

Myeloid neoplasms with PDGFR abnormalities (WHO types)

Hematopoietic neoplasms with FGFR1 abnormalities (WHO types)

Smoldering systemic mastocytosis

Aggressive systemic mastocytosis

Mast cell leukemia

Neoplasms in which eosinophils may or may not be part of the malignant clone

Other MPN with eosinophilia*

MDS with eosinophilia

Other MDS/MPN overlap syndromes with eosinophilia*

Indolent systemic mastocytosis

Neoplasms in which eosinophils usually are not part of the malignant clone

Hodgkin disease

B-or T-cell non-Hodgkin lymphoma

Acute lymphoblastic leukemia

Chronic lymphocytic leukemia

Langerhans cell histiocytosis

*Other MPN or MPN/MDS: neoplasms where no abnormalities in the PDGFR or FGFR1 genes are detectable.

CEL, chronic eosinophilic leukemia; PDGFR, platelet-derived growth factor receptor; FGFR, fibroblast growth factor receptor; MPN, myeloproliferative neoplasm (s); MDS, myelodysplastic syndrome(s).

WHO, World Health Organization.