Table 1. SNPs between E112/10 and the E. coli outbreak German isolates.

Position in 2011C-3493	Position in TY2482, rotated	SNP	Loca	Nb	AAc	Locus tag	Gene	Annotation	Strain
374280	4079071	C->A	CDS	N	D->E	O3K_01800	ugpB	glycerol-3-phosphate transporter periplasmic binding protein	E112/10
380310	4073041	G->A	CDS	S	–	O3K_01830	ggt	gamma-glutamyltranspeptidase	E112/10
680072	3773277	A->G	CDS	N	F->S	O3K_03335	–	hypothetical protein	E112/10
1135122	3317489	C->T	CDS	N	A->T	O3K_05510	sdaB	L-serine deaminase II	E112/10
1348726	3103699	A->T	CDS	S	-	O3K_06535	nadB	quinolinate synthase, L-aspartate oxidase	E112/10
1413160	3039265	C->T	CDS	N	P->L	O3K_06820	pbpC	penicillin-binding protein 1C	E112/10
1649869	2802473	C->A	CDS	N	R->L	O3K_07975	–	NAD dependent epimerase/dehydratase family protein	E112/10
2087027	2365134	G->A	CDS	N	S->F	O3K_09945	fliF	flagellar MS-ring protein	E112/10
2212137	2240010	C->T	CDS	S	–	O3K_10675	zwf	glucose-6-phosphate 1-dehydrogenase	E112/10
2413202	2038897	C->T	CDS	N	G->S	O3K_11765	–	acetyl-CoA: acetoacetyl-CoA transferase subunit alpha/beta	E112/10
2461442	1990657	A->T	CDS	N	Y->N	O3K_11980	nemA	N-ethylmaleimide reductase	E112/10
3235407	1215568	C->T	CDS	N	L->F	O3K_15870	pgaB	outer membrane N-deacetylase	E112/10
3239060	1211915	T->C	ig	–	–	–	–	–	E112/10
3288859	1161972	A->G	CDS	S	–	O3K_16115	–	hypothetical protein	E112/10
3313293	1137538	G->A	CDS	N	V->I	O3K_16290	–	regulatory protein	E112/10
3520805	930095	T->G	CDS	N	L->V	O3K_17215	moeB	molybdopterin biosynthesis protein MoeB	E112/10
4130999	319547	C->T	ig	–	–	–	–	–	E112/10
4157098	293448	C->T	ig	–	–	–	–	–	E112/10
4373593	76954	A->G	CDS	N	E->G	O3K_21210	sgrR	transcriptional regulator SgrR	E112/10
4518367	5211133	G->A	CDS	N	A->T	O3K_21840	–	inner membrane protein	E112/10
4667748	5061192	G->A	CDS	N	V->I	O3K_22600	–	putative cell envelope opacity-associated protein	E112/10
5176186	4552535	C->T	CDS	N	R->H	O3K_24910	rffA	TDP-4-oxo-6-deoxy-D-glucose transaminase	E112/10
174510	4279463	A->C	CDS	N	N->H	O3K_00895	selB	selenocysteinyl-tRNA-specific translation factor	Outbreak
605339	3848010	T->C	CDS	N	I->M	O3K_02960	-	putative calcium/sodium:proton antiporter	Outbreak
624647	3828702	A->G	CDS	N	T->A	O3K_03070	–	hydrolase, inner membrane	Outbreak
1438448	3013977	A->C	CDS	N	E->D	O3K_06930	upp	uracil phosphoribosyltransferase	Outbreak
1584996	2867346	A->G	CDS	N	R->G	O3K_07665	–	portal protein p19d	Outbreak
1757038	2695256	A->G	CDS	N	H->R	O3K_08425	napG	quinol dehydrogenase periplasmic component	Outbreak
1883285	2569009	T->C	CDS	S	–	O3K_08990	gatC	PTS system galactitol-specific transporter subunit IIC	Outbreak
1951216	2500990	G->A	CDS	S	-	O3K_09260	-	Wzx	Outbreak
2288948	2163199	G->A	ig	–	–	–	–	–	Outbreak
2668508	1783405	A->G	CDS	N	I->V	O3K_13035	gadC	glutamate/gamma-aminobutyrate antiporter	Outbreak
2859175	1592738	G->A	CDS	N	R->Q	O3K_13895	–	oxidoreductase	Outbreak
3956440	494106	G->A	CDS	N	T->I	O3K_19295	lon	DNA-binding ATP-dependent protease La	Outbreak
4039977	410569	A->G	CDS	N	W->R	O3K_19710	mhpT	putative 3-hydroxyphenylpropionic transporter MhpT	Outbreak
4078362	372184	T->G	CDS	N	*->Y	–	–	putative deaminase/amidohydrolase	Outbreak
4518246	5211254	T->G	ig	–	–	–	–	–	Outbreak
5053944	4674752	A->G	CDS	N	E->G	O3K_24345	rhaB	rhamnulokinase	Outbreak

^aLoc = Location of the mutation. CDS: inside a coding sequence; ig: intergenic.

^bN = Type of nucleotide substitution. N: nonsynonymous substitution; S: synonymous substitution; -: not applicable.

^cAA = Amino acid change.

^dSNP not present in 2009EL-2050.