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. 2013 May 10;8(5):e58701. doi: 10.1371/journal.pone.0058701

Figure 2. Infusion of norBNI into the ventral hippocampus (VH) reduces the renewal of fear.

Figure 2

A. Microinfusion cannula placements in the VH for all rats included in Experiment 1 mapped onto coronal sections from the atlas of Paxinos and Watson (2007). Numbers indicate distance from bregma in millimeters. Animals received 10 µg of norBNI (black circles), 5 µg of norBNI (gray triangles), or saline (white circles). B. Mean (±SEM) CS-elicited freezing during extinction training. Each extinction block consists of 3 CS presentations. C. Mean (+SEM) difference scores (pre-CS freezing subtracted from CS-elicited freezing) during test in the training (A) context and the extinction (B) context. * denotes norBNI-treated animals showed significantly less freezing to the CS than saline-treated animals (p<0.01).