Percentage EUD gain in IFD plans constructed with different mixing factors m (i.e., relative weight of FTP) for a representative patient case. The physical dose of the IFD plans was renormalized to eliminate any increase of rectal or bladder EUD. A range of α/β-values was considered. The solid lines correspond to α/β of 1.5 Gy for GTV, 8 Gy for rectum, and 3 Gy for bladder, and nominal beam range. The shadowed bands correspond to the likely interval of the ΔEUD% due to (a) the uncertainty of α/β (±0.5 Gy for GTV, ±2 Gy for rectum, ±1 Gy for bladder) and (b) range shift (2.5 mm SD).