Table 2.
Impact of age at diagnosis and late presentation with HIV on mortality
| N = 1965 | Rate/1000 pyrs (95% CI) | Univariable rate ratio (95% CI) | p-value | Multivariable rate ratio (95% CI) | p-value |
|---|---|---|---|---|---|
|
Age at HIV diagnosis (years) |
|
|
<0.0001 |
|
<0.0001 |
| <50 |
13.16(10.79-16.06) |
1 |
|
1 |
|
| >50 |
35.65(24.92-50.98) |
2.70(1.80-4.08) |
|
2.88(1.88-4.40) |
|
|
CD4 count at diagnosis Cells/mm3 |
|
|
<0.0001 |
|
<0.0001 |
| >350 |
7.59(5.16-11.14) |
1 |
|
1 |
|
| <350 |
16.65(12.75-21.74) |
2.19(1.37-3.50) |
|
2.99(1.80-4.95) |
|
| Unknown |
30.53(22.94-40.63) |
4.02(2.49-6.50) |
|
6.60(3.86-11.28) |
|
|
Calendar period |
|
|
<0.0001 |
|
<0.0001 |
| 1996-2001 |
42.61(31.81-57.06) |
1 |
|
1 |
|
| 2002-2005 |
12.91(9.13-18.26) |
0.30(0.19-0.48) |
|
0.37(0.23-0.58) |
|
| 2006-2010 |
10.69(8.10-14.11) |
0.25(0.17-0.38) |
|
0.31(0.21-0.47) |
|
|
Sex/HIV risk group |
|
|
0.06 |
|
0.43 |
| MSM |
14.20(11.53-17.50) |
1 |
|
1 |
|
| Female heterosexual |
12.73(7.39-21.93) |
0.90(0.50-1.61) |
|
0.90(0.46-1.78) |
|
| Male heterosexual |
26.16(17.54-39.03) |
1.84(1.17-2.89) |
|
1.45(0.90-2.35) |
|
| Others |
26.16(6.54-104.60) |
1.84(0.45-7.48) |
|
1.26(0.31-5.14) |
|
|
Ethnicity |
|
|
0.09 |
|
0.04 |
| Caucasian |
15.21(12.56-18.41) |
1 |
|
1 |
|
| African/Caribbean |
12.53(7.28-21.58) |
0.82(0.46-1.47) |
|
1.05(0.53-2.10) |
|
| Others |
33.55(17.46-64.49) |
2.21(1.12-4.36) |
|
2.78(1.37-5.62) |
|
|
ART status |
|
|
0.01 |
|
<0.0001 |
| Not on ART |
20.81(15.81-27.38) |
1 |
|
1 |
|
| On ART | 13.20(10.54-16.52) | 0.63(0.44-0.90) | 0.33(0.22-0.50) |