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. 2013 Apr 26;7:34. doi: 10.1186/1752-0509-7-34

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Copyright © 2013 Martinez-Pasamar et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dynamics of activated MOG-T_eff, MOG-Treg cells and microglia in secondary lymphoid organs and CNS during the course of EAE. A) Percentage of MOG-specific T_eff (red) or T_reg (blue) in the spleen after immunization. The upper graph shows the mean of the measurements from 3 animals each day for both populations (T_eff and T_reg) together. The bottom panels show the distribution of all measurements (raw data) from 3 animals per day for each subpopulation as dots, with the mean in black; B) percentage of MOG-specific T_eff (red) or T_reg (blue) in the CNS from day 9 after immunization. The upper graph shows the mean of the measurements from 3 animals each day, while the bottom panels show the distribution of all measurements for each subpopulation as dots, with the mean in black; C) Clinical score of animals suffering EAE after immunization (mean + SD); D) Percentage of activated microglia in the CNS from day 9 after immunization.