Figure 5.
Dynamics of activated MOG-Teff, MOG-Treg cells and microglia in secondary lymphoid organs and CNS during the course of EAE after B cell depletion. A) Percentage of MOG-specific Teff (red) or Treg (blue) cells in the spleen after immunization. The upper graph shows the mean of measurements from 3 animals each day, and the bottom panels show the distribution of all measurements for each subpopulation as dots, with the mean in black; B) percentage of MOG-specific Teff (red) or Treg (blue) cells in the CNS from day 9 after immunization. The upper graph shows the mean of measurements from 3 animals each day, and the bottom panels show the distribution of all measurements for each subpopulation as dots, with the mean in black; C) clinical score of animals suffering EAE after B cell depletion (mean + SD); D) percentage of activated microglia in the CNS from day 9 after immunization.