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. Author manuscript; available in PMC: 2013 May 10.
Published in final edited form as: Free Radic Biol Med. 2009 Jul 22;47(8):1140–1146. doi: 10.1016/j.freeradbiomed.2009.07.025

Fig. 2.

Fig. 2

Effects of human endotoxemia on plasma fibrinogen, nitrated fibrinogen, and ex vivo fibrin clotting kinetics. (A) Paired t test statistical comparison before and 72 h after LPS administration reveals a significant increase in nitrated fibrinogen levels after the inflammatory stimulus. (B) The same analysis reveals a significant increase in the levels of fibrinogen in plasma. (C) The fibrinogen concentration was adjusted to 0.5 mg/ml with TBS and fibrin clot formation was initiated by the simultaneous addition of calcium and thrombin. The curves represent the average ± SEM of 22 individual samples before (□) and 72 h after (Δ) LPS injection and demonstrate an increased velocity of fibrin clot formation after LPS (P=0.029). (D) Spearman correlation between levels of fibrinogen nitration and initial velocity of fibrin clot formation 72 h after endotoxin (r=0.42, P=0.04, N=23).