Table 3. Table 3A: Correlations of cardiovascular risk factors with fibrinogen and nitrated fibrinogen.

	Spearman's correlation coefficients

	Fibrinogen	Nitrated fibrinogen
HDL cholesterol	0.021	0.085
Apolipoprotein A-I	−0.050	0.022
Apolipoprotein A-II	0.059	0.012
LDL cholesterol	0.069	0.027
Apolipoprotein B	0.093	0.023
Triglycerides	−0.022	−0.019
C-reactive protein	0.300§	0.174†
Serum amyloid A	0.341§	0.242§
Body mass index	0.224§	0.017
Waist circumference	0.175‡	0.079
Insulin	0.214§	−0.022

	P values: † ≤ 0.01; ‡ ≤ 0.001, § ≤ 0.0001.

Table 3B Multivariable associations of cardiovascular risk factors with fibrinogen and nitrated fibrinogen

Covariate	Regression coefficients (95% confidence interval)

	Fibrinogen		Nitrated fibrinogen

	Model 1	Model 2	Model 1	Model 2	Model 3
Ln-HDL cholesterol	−0.20 (−0.44 to 0.05)		1.30 (−2.84 to 5.44)
Ln-apolipoprotein A-I	−0.52 (−0.93 to −0.10)^*		0.22 (−6.95 to 7.38)
Ln-apolipoprotein A-II	0.12 (−0.33 to 0.57)		0.45 (−7.15 to 8.05)
Ln-LDL cholesterol	0.31 (0.04 to 0.59)^*	0.32 (0.04 to 0.61)^*	2.53 (-2.28 to 7.33)
Ln-apolipoprotein B	0.44 (0.08 to 0.81)^*		3.41 (-2.61 to 9.43)
Ln-triglycerides	0.030 (−0.10 to 0.16)		0.29 (−1.93 to 2.50)
Ln-C reactive protein	0.28 (0.16 to 0.40)^§	0.14 (0.05 to 0.23)^†	4.0 (2.03 to 5.86)^§	4.84 (2.58 to 7.09)^‡	3.63 (0.71 to 4.78)^†
Ln-serum amyloid A	0.22 (0.13 to 0.31)^§	0.12 (0.05 to 0.20)^‡	2.86 (1.39 to 4.32)^§	2.83 (1.23 to 4.43)^‡	2.14 (0.60 to 3.67)^†
Waist circumference	0.10 (0.05 to 0.15)^‡		0.69 (−0.24 to 1.62)
Ln-insulin	0.22 (0.09 to 0.35)^‡		0.68 (−1.51 to 2.87)

Results of linear regression modeling are presented as the change in level of dependent variables (ﬁbrinogen, nitrated ﬁbrinogen) for a one unit increase in level of independent variables. Model 1 was adjusted for age, gender, and race; Model 2 for age, gender, race BMI, blood pressure, LDL cholesterol, and exercise; Model 3 also included ﬁbrinogen values. P values:

< 0.05,

^†

≤ 0.01;

^‡

≤ 0.001,

^§

≤ 0.0001.