Table 1.
Mean numbers of SNPs and prognostic SNPs included in fitted prediction models, recovery rate and means/standard deviations of the log-rank p-value from test sets for the proposed method and methods assuming recessive, dominant, or multiplicative models for all SNPs
|
Censoring |
ρ |
Genetic |
Mean number |
Mean number of |
Recovery |
Mean (SD) p-value |
|---|---|---|---|---|---|---|
| |
|
model |
of selected |
of selected |
rate |
of the log-rank |
| SNPs | prognostic SNPs | test | ||||
| 30% |
0 |
Proposed |
6.72 |
5.05 |
0.75 |
<0.0001 (<0.0001) |
| |
|
Recessive |
8.03 |
4.01 |
0.50 |
0.0052 (0.0018) |
| |
|
Dominant |
6.66 |
3.85 |
0.58 |
<0.0001 (<0.0001) |
| |
|
Multiplicative |
7.72 |
4.95 |
0.64 |
0.0004 (0.0003) |
| |
0.3 |
Proposed |
6.51 |
4.83 |
0.74 |
0.0001 (0.0001) |
| |
|
Recessive |
7.73 |
3.83 |
0.50 |
0.0045 (0.0016) |
| |
|
Dominant |
6.58 |
3.66 |
0.56 |
0.0011 (0.0007) |
| |
|
Multiplicative |
7.52 |
4.72 |
0.63 |
0.0006 (0.0004) |
| 15% |
0 |
Proposed |
6.65 |
5.18 |
0.78 |
<0.0001 (<0.0001) |
| |
|
Recessive |
8.59 |
4.19 |
0.49 |
0.0028 (0.0011) |
| |
|
Dominant |
6.69 |
3.88 |
0.58 |
<0.0001 (<0.0001) |
| |
|
Multiplicative |
7.96 |
4.98 |
0.63 |
0.0005 (0.0005) |
| |
0.3 |
Proposed |
6.37 |
4.98 |
0.78 |
<0.0001 (<0.0001) |
| |
|
Recessive |
7.88 |
3.94 |
0.50 |
0.0048 (0.0028) |
| |
|
Dominant |
6.38 |
3.74 |
0.59 |
0.0011 (0.0011) |
| Multiplicative | 7.55 | 4.89 | 0.65 | 0.0001 (<0.0001) |