Figure 4.

Dependence on the number of peptides injected. The relative number of cancer cells after one year of treatment compared to the tumour size at the beginning of the simulation is depicted. The mean number of cancer cells at the end of simulation is shown. Data were obtained from 500 simulations. Number of peptides for each type of MHC is given in the legend, e.g. 1 pep I: one peptide binding to MHC I. The MHC-genotype is HLA-A*03 | HLA-B*44 | HLA-C*04 | HLA-DRB1*04 | HLA-DQA1/DQB1 | HLA-DPA1/DPB1. For all experiments one hundred initial cancer cells were simulated within 5 μl of blood that were treated with injections of peptides emulgated in adjuvant starting at time point zero and being repeated five times at an interval of 28 days. The antigen 7B2_HUMAN (Neuroendocrine protein 7B2) was chosen from over-expression data in kidney tumours.