Table 3.

Genes encoding molecules with predicted transmembrane domains and/or a signal peptide are significantly enriched among mab-5-regulated genes

	Down in lof	Up in lof	Down in gof	Up in gof	Total
Fraction in gene set1	24/37	5/9	100/128	52/82	181/256
Binomial p value2	p = 0.0368	p = 0.1702	p < 0.0001	p = 0.0129	p < 0.0001

¹This set includes only protein-encoding genes and not small RNA genes. From gene annotation files from Wormbase, there were 9546 genes with tmhmm and/or SignalP annotation out of 19245 total.

²Binomial distribution test comparing fractions of transmembrane and secreted proteins in the gene sets compared to the total fraction in the genome.