AEs and temperature after challenge. AEs and body temperature were recorded daily after challenge. Blood-stage challenge (A1) and sporozoite challenge (A2): mean number of possibly or probably related solicited AEs per subject. Blood-stage challenge (B1) and sporozoite challenge (B2): temperature (mean +SEM). Black line, group 1 (CPS-immunized, blood-stage challenge; n = 9); dashed dark gray line, group 3 (controls, blood-stage challenge; n = 5); light gray line, group 2 (CPS-immunized, sporozoite challenge; n = 5); dashed light gray line, group 4 (controls, sporozoite challenge; n = 5).